Formulasi tablet ekstrak buah mangrove (Rhizophora mucronata): variasi konsentrasi Avicel PH 101 dan PVP K-30

Formulation of mangrove fruit (Rhizophora mucronata) extract tablets: variation in concentration of Avicel PH 101 and PVP K-30

Abstract

Hepatoprotectors are compounds that have cell-protective properties and repair damaged liver tissue due to the influence of toxic substances. Mangrove fruit (Rhizophora mucronata) contains flavonoids, tannins, and saponins. The presence of these chemical compounds indicates a hepatoprotective mechanism. To utilise this potential, a Formulation of mangrove fruit extract tablets was made with a combination of PVP K-30 as a binder and Avicel PH 101 as a disintegrant. This study aims to determine the effect of PVP K-30 and Avicel PH 101 on the physical properties of mangrove fruit extract granules and tablets. The method is the wet granulation. Granule evaluation includes organoleptics, compressibility, flow time, and angle of repose. Tablet evaluations include organoleptics, weight uniformity, friability, hardness, and disintegration time. This research shows that concentrations of Avicel PH 101 and PVP K-30 affect granule testing in the form of compressibility, flow time, and angle of repose. In addition, it also affects tablet evaluation in the form of weight uniformity, hardness, friability, and disintegration time. This study concludes that Formula 2 is the best, considering physical and statistical analysis.